| Date | Home team | Result | Guest team |
|---|---|---|---|
| 23. July 2021 20:45 | Standard de Liège  |
1 - 1 |  KRC Genk |
| 24. July 2021 16:15 | OH Leuven  |
1 - 1 |  SV Zulte Waregem |
| 24. July 2021 18:30 | KFCO Beerschot Wilrijk  |
0 - 1 |  Cercle Brugge |
| 24. July 2021 18:30 | KV Kortrijk  |
2 - 0 |  RFC Seraing |
| 24. July 2021 20:45 | KV Ostende  |
0 - 3 |  Sporting Charleroi |
| 25. July 2021 13:30 | YR KV Mechelen  |
3 - 2 |  R. Antwerp FC |
| 25. July 2021 16:00 | Club Brugge KV  |
2 - 2 |  KAS Eupen |
| 25. July 2021 18:30 | RSC Anderlecht  |
1 - 3 |  R. Union Saint Gilloise |
| 25. July 2021 21:00 | Sint Truiden VV  |
2 - 1 |  KAA Gent |
* Dates not yet confirmed and therefore subject to change.